Administrative command prompt:
net stop “update services”
net stop w3svc
Run as admin:
Start > All Programs > Microsoft SQL Server 2005 > SQL server Management Studio Express
Connect to server name: \\.\pipe\MSSQL$MICROSOFT##SSEE\sql\query
Databases > SUSDB > Right Click > Detach
Tick the “Drop Connections” and click OK.
Navigate to the SUS database folder on C:\ copy/paste it to the desired location using windows explorer.
Back in SQL server Management Studio Express choose “Add”
Add the database in the new location and click OK, OK.
Delete the old database files from C:\
Source: itblog
Source: petenetlive